Table 3.
Pathways altered by cit-AgNPs and PVP-AgNPs.
| Pathway | P value | Gene Count | Genes | |
|---|---|---|---|---|
| Upregulated | Downregulated | |||
| Cit-AgNPs | ||||
| Keap1-Nrf2* | 1.00E-06 | 4 | Cebpb | Gsta2, Gclc, Nfe2l2 |
| White fat cell differentiation | 1.70E-05 | 4 | Cebpb, Foxo1 | Nr2f2, Srebf1 |
| Adipogenesis genes | 5.00E-05 | 6 | Lpin1, Cebpb, Foxo1, Lifr | Irs 1, Srebf1 |
| PluriNetWork | 5.98E-04 | 7 | Lifr, Pim3, Rock2 | Nr2f2, Irs1, Zfp143, Ocln |
| IL-1 signaling | 8.36E-04 | 3 | II1r1, II1r2 | Irak2 |
| Focal Adhesion-PI3K-Akt-mTOR | 1.13E-03 | 7 | Pfkfb1, Pfkfb3, Foxo1 | Efna1, Lpar6, Srebf1, Irs 1 |
| ID signaling | 2.08E-03 | 3 | Srebf1, Irs1, Id2 | |
| PPAR signaling* | 7.51E-03 | 3 | Acsl4 | Acaa1a, Acaa1b |
| MAPK signaling* | 9.46E-03 | 4 | II1r2, II1r1 | Gstt2, Gsta2 |
| IL-6 signaling* | 1.25E-02 | 3 | Cebpb, Foxo1 | Erbb3 |
| IL-7 signaling | 1.93E-02 | 2 | Foxo1 | Irs 1 |
| ErbB signaling | 2.10E-02 | 2 | Nrg4 | Erbb3 |
| Exercise-induced circadian regulation* | 2.37E-02 | 2 | Cebpb | Nr1d1 |
| Glycolysis* | 2.55E-02 | 2 | Pfkfb 1 | Pfkfb3 |
| Lung fibrosis | 3.87E-02 | 2 | Cebpb | Nfe2l2 |
| Ptf1a related regulatory pathway | 4.74E-02 | 1 | Prox1 | |
| PVP-AgNPs | ||||
| TCA cycle | 1.52E-04 | 5 | Dlst, Pdk2, Mdh2, Sdhd, Idh3g | |
| Fatty acid biosynthesis | 4.44E-04 | 4 | Fasn, Acsl5, Echdc3, Acsl1 | |
| Glycolysis & gluconeogenesis | 1.46E-03 | 5 | Pklr, Got2, Mdh2, Pgam1, Eno1 | |
| Electron transport chain | 1.65E-03 | 7 | Ndufa10, Ndufb9, Slc25a5, Ndufa3, Sdhd, Uqcrc2, Ndufs8 | |
| Mitochondrial LC-fatty acid p-oxidation | 2.21E-03 | 3 | Cpt2, Ehhadh, Acsl1 | |
| MAPK signaling* | 2.26E-03 | 9 | Gstt1, Mapk3, Hspb1, Gsta4, Gstm2, Gstm3, Gstm4,Gsta1, Gsta2 | |
| Complement activation | 2.65E-03 | 3 | C4a, C4b, Hc | |
| Fatty acid beta oxidation | 2.68E-03 | 4 | Acsl1, Cpt2, Crat, Acsl5 | |
| Glutathione metabolism | 3.68E-03 | 3 | Gstm2, Gstt1, Gstm7 | |
| Glycolysis* | 1.04E-02 | 4 | Pklr, Eno1, Pgam1, Pdk2 | |
| PPAR signaling* | 1.22E-02 | 5 | Acsl1, Cpt2, Ehhadh, Acsl5, Pltp | |
| Oxidative phosphorylation | 1.51E-02 | 4 | Ndufa3, Ndufb9, Ndufa10, Ndufs8 | |
| Glycogen metabolism | 1.89E-02 | 3 | Pygl, Ugp2, Ppp2r1a | |
| Keap1-Nrf2* | 2.22E-02 | 2 | Nfe2l2,Gsta2 | |
| IL-6 signaling* | 2.54E-02 | 5 | Hsp90aa1, Erbb3, Ppp2r1a, Hspb1, Mapk3 | |
| Urea cycle & metabolism of amino groups | 4.34E-02 | 2 | Otc, Gamt | |
| Exercise-induced circadian regulation* | 4.85E-02 | 3 | Ugp2, Gstm3, Nr1d1 | |
Pathway analysis was performed using TAC.
*,
common pathways modulated by cit-AgNPs and PVP-AgNPs.