Table 4.
mRNAs-lncRNAs co-expression.
| Gene | Gene description | Associated Pathway | No. of lncRNAs | ||
|---|---|---|---|---|---|
| Total No. | (−) correlation | (+) correlation | |||
| Cit-AgNPs | |||||
| Cebpb | CCAAT/enhancer-binding protein | Keap1-Nrf2 | 5 | 2 | 3 |
| Gclc | glutamate—cysteine ligase catalytic subunit | Keap1-Nrf2 | 5 | 2 | 3 |
| Gsta2 | glutathione S-transferase A2 | Keap1-Nrf2, MAPK | 2 | 1 | 1 |
| Gstt2 | glutathione S-Transferase theta 2 | MAPK | 3 | 1 | 2 |
| II1r1 | Interleukin 1 receptor, type I | MAPK, IL-1 signaling | 1 | 0 | 1 |
| Irak2 | Interleukin-1 receptor-associated kinase-like 2 | IL-1 signaling | 4 | 2 | 2 |
| Srebf1 | sterol regulatory element-binding transcription factor 1 | Focal Adhesion-PI3K-Akt-mTOR signaling | 3 | 2 | 1 |
| Pfkfb3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Focal Adhesion-PI3K-Akt-mTOR signaling | 2 | 1 | 1 |
| Efna1 | ephrin A1 | Focal Adhesion-PI3K-Akt-mTOR signaling | 2 | 1 | 1 |
| Acaa1a | acetyl-Coenzyme A acyltransferase 1A | PPAR | 6 | 1 | 5 |
| Acaa1b | acetyl-Coenzyme A acyltransferase 1B | PPAR | 2 | 1 | 1 |
| PVP-AgNPs | |||||
| Dlst | dihydrolipoamide S-succinyltransferase | TCA cycle | 8 | 6 | 2 |
| Pdk2 | pyruvate dehydrogenase kinase, isoenzyme 2 | TCA cycle | 4 | 2 | 2 |
| Mdh2 | malate dehydrogenase 2, NAD (mitochondrial) | TCA cycle Glycolysis & Gluconeogenesis |
3 | 2 | 1 |
| Idh3g | isocitrate dehydrogenase 3 (NAD+), gamma | TCA cycle | 13 | 11 | 2 |
| Sdhd | succinate dehydrogenase complex, subunit D | TCA cycle Electron transport Chain |
21 | 5 | 16 |
| Ndufs8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8 | Electron transport chain | 12 | 11 | 1 |
| Ndufb9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 | Electron transport chain | 13 | 3 | 10 |
| Pklr | pyruvate kinase liver and red blood cell | Glycolysis & gluconeogenesis | 12 | 9 | 3 |
| Eno1 | enolase 1, alpha non-neuron | Glycolysis & gluconeogenesis | 16 | 3 | 13 |
| Gsta2 | glutathione S-transferase A2 | MAPK, Keap1-Nrf2 | 6 | 1 | 5 |
| Gstt1 | glutathione S-transferase theta 1 | MAPK | 10 | 9 | 1 |
| Mapk3 | mitogen-activated protein kinase 3 | MAPK, IL-6 signaling | 20 | 18 | 2 |
| Hspb1 | heat shock protein 1 | MAPK, IL-6 signaling | 9 | 7 | 2 |
| Cpt2 | carnitine palmitoyltransferase 2 | Fatty Acid Beta Oxidation, PPAR | 5 | 5 | 0 |
| Crat | carnitine acetyltransferase | Fatty Acid Beta Oxidation | 9 | 3 | 6 |
| Acsl5 | acyl-CoA synthetase long-chain family member 5 | Fatty Acid Beta Oxidation, PPAR | 4 | 1 | 3 |
| Ehhadh | enoyl-Coenzyme A hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | PPAR | 4 | 1 | 3 |
| Pltp | phospholipid transfer protein | PPAR | 18 | 18 | 0 |
| Hsp90aa1 | heat shock protein 90, alpha, class A member 1 | IL-6 signaling | 16 | 15 | 1 |
| Ppp2r1a | protein phosphatase 2 regulatory subunit A (PR 65), alpha | IL-6 signaling | 23 | 18 | 5 |
Differentially expressed mRNA, the associated pathway and the number of total, negatively (−) and positively (+) correlated lncRNAs are shown. Pathway information is derived from TAC analysis.