Table 1.
Patient, procedural, and outcome metrics of stroke patients treated with mechanical thrombectomy at the 28 international sites and divided by COVID-19 status
| All patients (n=458) | COVID-19 positive patents (n=13) | Non-COVID-19 patients (n=445) | P-value* | |
| Age, median (IQR) | 71 (60–80) | 58 (50–71) | 72 (60–80) | 0.04 |
| Females, n (%) | 210 (45.9%) | 5 (38.5%) | 205 (46.1%) | 0.779 |
| White, n (%) | 310 (67.7%) | 6 (46.2%) | 304 (68.3%) | 0.129 |
| LKN to hospital door, median (IQR) | 260 (119–506) | 202 (92–606) | 260 (119–506) | 0.557 |
| Admission NIHSS, median (IQR) | 16 (10–21) | 19 (16–24) | 15 (10–20) | 0.047 |
| IV-tPA, n (%) | 184 (40.2%) | 4 (30.8%) | 180 (40.4%) | 0.576 |
| ASPECTS, median (IQR)† | 8 (7–10) | 9 (8–10) | 8 (7–10) | 0.249 |
| Posterior circulation, n (%) | 46 (10%) | 0 | 46 (10.3%) | 0.38 |
| Intubation, n (%) | 241 (52.6%) | 5 (38.5%) | 236 (53%) | 0.4 |
| Door to groin, median (IQR) | 81 (50–127) | 56 (37–150) | 82 (50–127) | 0.315 |
| LKN to groin, median (IQR) | 351 (200–654) | 259 (181–343) | 355 (200–659) | 0.118 |
| Number of passes during thrombectomy, median (IQR) | 2 (1–3) | 2 (1–4) | 2 (1–3) | 0.189 |
| Successful recanalization (mTICI ≥2 b), n (%) | 381 (83.2%) | 13 (100%) | 368 (82.7%) | 0.138 |
| Procedure duration, median (IQR) | 40 (24–66) | 45 (29–76) | 40 (24–66) | 0.455 |
| Door to reperfusion, median (IQR) | 120 (75–178) | 86 (35–154) | 122 (76–178) | 0.064 |
| Length of stay, median (IQR) | 5 (3–10) | 8 (4–15) | 5 (3–10) | 0.231 |
| sICH, n (%) | 28 (6.1%) | 2 (15.4%) | 26 (5.8%) | 0.185 |
| In-hospital mortality, n (%)‡ | 80 (24.4) | 4 (33.3%) | 76 (24.1%) | 0.496 |
| DC mRS, median (IQR)‡ | 4 (2–5) | 4 (3–6) | 4 (2–5) | 0.443 |
| Functional independence on discharge (mRS 0–2), n (%)‡ | 96 (29.2%) | 2 (16.7%) | 94 (29.7%) | 0.52 |
*Calculated using Fisher's exact test for categorical variables and Wilcoxon test for the continuous variables.
†Only for patients with anterior circulation occlusion.
‡Missing for 130 patients.
ASPECTS, Alberta Stroke Program Early CT score; COVID-19, coronavirus disease of 2019; IV-tPA, intravenous tissue plasminogen activator; LKN, last known normal; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institute of Health Stroke Scale; sICH, symptomatic intracerebral hematoma.