Table 1. Hemodynamics, blood hematocrit, hemoglobin, lactate, and arterial partial pressure of CO2 levels throughout experiment.
| Baseline | Hct 30% | Hct 25% | Hct 20% | Hct 15% | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MAP (mmHg) | ||||||||||
| Control | 92±14 | 80±4 | 80±11 | 80±10 | 84±10 | |||||
| Balanced HES | 95±10 | 66±1* | 60±1* | 58±4* | 56±5* | |||||
| Balanced crystalloid | 87±10 | 66±11* | 54±4* | 54±8* | 47±7* | |||||
| NaCl % 0.9 | 90±12 | 61±5* | 56±5* | 50±2* | 42±5* | |||||
| CVP (mmHg) | ||||||||||
| Control | 7±1 | 7±1 | 6±2 | 6.5±1.5 | 7±1 | |||||
| Balanced HES | 6±1 | 6±1 | 7±1 | 6.9±1.3 | 7±1 | |||||
| Balanced crystalloid | 6±1 | 7±1 | 7±2 | 7±2 | 7±2 | |||||
| NaCl % 0.9 | 5±1* | 5±1* | 6±1# | 6±1# | 6±1*# | |||||
| Hemoglobin (g/dl) | ||||||||||
| Control | 14.2±0.5 | 13.5±1.1 | 12.9±1 | 13.6±1.1 | 12.2±1.3 | |||||
| Balanced HES | 14.6±0.8 | 9.6±0.5* | 7.9±0.7* | 6.2±0.4* | 4.6±0.4* | |||||
| Balanced crystalloid | 14.9±0.8 | 9.9±0.9* | 7.8±0.6* | 6.2±0.3* | 4.7±0.4* | |||||
| NaCl % 0.9 | 14.3±1.4 | 10.1±0.3* | 8±0.4* | 6.5±0.5* | 4.8±0.2* | |||||
| Hematocrit (%) | ||||||||||
| Control | 44±1 | 41±3 | 40±3 | 41±4 | 37±4 | |||||
| Balanced HES | 45±2 | 30±2* | 25±1* | 20±1* | 15±2* | |||||
| Balanced crystalloid | 46±3 | 31±2* | 25±2* | 20±1* | 15±1* | |||||
| NaCl % 0.9 | 45±4 | 31±1* | 25±1* | 21±1* | 15±1* | |||||
| pH | ||||||||||
| Control | 7.42±0.05 | 7.40±0.02 | 7.42±0.03 | 7.42±0.02 | 7.41±0.02 | |||||
| Balanced HES | 7.45±0.03 | 7.44±0.03 | 7.44±0.04 | 7.40±0.03 | 7.39±0.03 | |||||
| Balanced crystalloid | 7.44±0.03 | 7.41±0.02 | 7.40±0.02 | 7.40±0.02 | 7.36±0.02* | |||||
| NaCl % 0.9 | 7.46±0.03 | 7.38±0.03 | 7.34±0.03*# | 7.31±0.03*# | 7.29±0.05*# | |||||
| HCO-3 (mmol/L) | ||||||||||
| Control | 21.3±1.7 | 20.1±2 | 18.9±0.8 | 19.2±1.4 | 20.4±1.2 | |||||
| Balanced HES | 20.9±1.2 | 23.1±1.2* | 24±1* | 23.5±1.5* | 23±1.6* | |||||
| Balanced crystalloid | 20.8±2.2 | 22±2.1* | 22.7±1.5* | 21.9±1.7* | 22.7±1.8* | |||||
| NaCl % 0.9 | 20.4±2.4 | 19.8±1.5+# | 19.1±1.5+# | 18.4±1.5+# | 16.8±1.5*+# | |||||
| Lactate (mmol/L) | ||||||||||
| Control | 0.9±0.3 | 1.2±0.3 | 1.2±0.6 | 1.5±0.5 | 1.5±0.5 | |||||
| Balanced HES | 0.9±0.2 | 1.1±0.3 | 1.3±0.5 | 2.1±0.8* | 2.7±1* | |||||
| Balanced crystalloid | 1.3±0.3 | 1.4±0.6 | 1.9±0.7* | 2.4±0.7* | 2.4±0.7* | |||||
| NaCl % 0.9 | 1.1±0.2 | 1.1±0.7 | 1.4±0.3* | 1.6±0.4# | 2.5±0.5* | |||||
| PaCO2 (mmHg) | ||||||||||
| Control | 34±5 | 33±4 | 30±1 | 30±1 | 33±3 | |||||
| Balanced HES | 31±3 | 35±4 | 36±4* | 39±3* | 39±2* | |||||
| Balanced crystalloid | 31±3 | 36±5 | 37±3* | 36±3* | 41±3* | |||||
| NaCl % 0.9 | 30±3 | 35±3 | 36±4* | 38±5* | 36±3# |
Hct: Hematocrit, MAP: Mean arterial pressure, HCO3 −: Bicarbonate, CVP: Central venous pressure, HES: Hydroxyethyl starch. Data are presented as mean±SD. *Adjusted P<0.05 versus control group, # adjusted P value versus balanced HES group