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. 2020 Jan 3;41(31):2983–2996. doi: 10.1093/eurheartj/ehz919

Figure 4.

Figure 4

Anti-senescence strategies. Akt, protein kinase B; AMPK, AMP-activated protein kinase; cGAS, cyclic GMP-AMP synthase; DPP4, dipeptidyl peptidase 4; FOXO, Forkhead box class O; HMGB-1, high-mobility group box 1; IL, interleukin; MAPK, mitogen-activated protein kinase; mTOR, mechanistic target of rapamycin; NF-κB, nuclear factor kappa B; NLRP3, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3; ox-vimentin, oxidized vimentin; PI3K, phosphoinositide 3-kinase; SASP, senescence-associated secretory phenotype; SIRT, sirtuin; STING, stimulator of interferon genes; TBK, serine/threonine-protein kinase TBK1; TNFα, tumour necrosis factor α.