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. Author manuscript; available in PMC: 2020 Nov 13.
Published in final edited form as: Sci Transl Med. 2020 May 13;12(543):eaaz0802. doi: 10.1126/scitranslmed.aaz0802

Fig. 5. HIV-1 dominates over the host promoter and drives NFATC3 expression downstream of HIV-1 integration site through aberrant splicing.

Fig. 5.

(A) HIV-1 LTR drives the transcription of NFATC3 through aberrant splicing from HIV-1 major splice donor (MSD) into host canonical splice acceptor site identified in HIV-1 SortSeq cells from an ART-treated, virally suppressed, HIV-1–infected individual. The HIV-1–host chimeric RNA junction is indicated as a dashed red arrow. (B) Transcription in the single cell (154_21) in which HIV-1 integrated into NFATC3. The expected transcription of upstream exons is indicated by magenta arrowheads, and the transcription of the downstream exons is indicated by red asterisks.