Figure 8. Schematic diagram of proposed mechanisms from this study’s findings.

BET inhibitor inhibits epigenetic reader proteins, such as Brd4, thus blocking the association of Brd4, H4K16ac, and p300 with Nox4 promoter region, which would downregulate the expression of Nox4 (and other genes) and, ultimately, restore lung capacity and improve lung fibrosis resolution.