Table 3:

Overall outcomes on SAP, E-N CLC and 24–7CLC, and influence of the order of treatment introduction SAP → E-N CLC → 24–7 CLC (Group A N=39), or in reverse (Group B N=38).

		SAP N=77	E-N N=77	24–7 N=77	P-Value
Percent time <3.9mmol/L /dL	Overall	4.0±3.3	2.3±1.7	1.8±1.4	<0.0001*
	Group A:	3.3±2.2	2.1±1.6	1.7±1.4	P=0.019†
	Group B:	4.9±3.9	2.6±1.9	2.0±1.4
Percent time in 3.9–10mmol/L	Overall	58.6±14.6	67.6±12.9	69.5±10.9	<0.0001*
	Group A:	59.0±13.1	69.3±10.4	69.4±9.8	p=0.68†
	Group B:	58.3±16.2	65.9±14.9	69.6±12.1
Percent time <3mmol/L	Overall	1.11±1.34	0.51±0.51	0.41±0.41	<0.0001*
	Group A:	0.70±0.54	0.40±0.39	0.37±0.41	p=0.0040†
	Group B:	1.54±1.74	0.63±0.60	0.47±0.42
Percent time >10mmol/L	Overall	37.4±16.5	30.1±13.7	28.7±11.4	<0.0001*
	Group	37.9±14.1	28.7±10.8	28.9±10.0	p=0.78†
	Group B:	36.9±18.7	31.5±16.2	28.5±12.8
Percent time >13.3mmol/L	Overall	12.6±10.5	8.6±7.5	7.3±5.9	<0.0001*
	Group A:	12.2±9.3	7.6±5.9	7.3±5.5	p=0.59†
	Group B:	13.0±11.7	9.6±8.8	7.4±6.4
Average CGM [mmol/L]	Overall	9.30±1.58	8.82±1.22	8.74±0.99	<0.0001*
	Group A:	9.36±1.38	8.70±0.96	8.75±0.88	p=0.63†
	Group B:	9.23±1.78	8.95±1.44	8.72±1.11
Coefficient of Variation [%]	Overall	37.8±4.5	35.3±4.2	34.3±4.0	<0.0001*
	Group A:	37.2±4.0	35.3±4.4	34.6±4.5	p=0.082†
	Group B:	38.5±5.4	35.4±3.9	34.0±3.6
Low Blood Glucose Index	Overall	1.04±0.79	0.66±0.42	0.57±0.34	<0.0001*
	Group A:	0.84±0.54	0.61±0.37	0.53±0.33	p=0.020†
	Group B:	1.24±0.95	0.72±0.48	0.60±0.35
High Blood Glucose Index	Overall	8.82±4.61	6.97±3.52	6.53±2.86	<0.0001*
	Group A:	8.85±4.12	6.54±2.74	6.55±2.59	p=0.99†
	Group B:	8.80±5.12	7.41±4.16	6.51±3.16

^*Comparison of SAP vs E-N CLC vs 24–7 CLC

^†Linear contrast of treatment escalation SAP → E-N CLC → 24–7 CLC (Group A) vs treatment de-escalation 24–7 CLC → E-N CLC → SAP (Group B).