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. 2020 Jul 23;5(14):e135317. doi: 10.1172/jci.insight.135317

Figure 2. Vegetation proteins predominantly originate in the circulation and inflammatory cells.

Figure 2

(A) Bioinformatics analysis revealed that human vegetation components of S. aureus (SA) and non–S. aureus (NSA) groups had largely similar origins. GO, Gene Ontology. (B) Venn diagram of the aggregate staphylococcal and non-staphylococcal vegetation proteome overlap with blood, platelet, and clot proteomes. (C) Venn diagram of the aggregate staphylococcal and non-staphylococcal vegetation proteome overlap with blood, platelet, clot, and neutrophil proteomes. (D) Bioinformatics analysis of vegetation proteins not shared with blood, platelet, clot, or neutrophil proteomes reveals many proteins annotated as extracellular. Some examples are shown at right (* indicates gene products that did not fit into the listed categories, namely AEBP1, PXDN, LRRC32, and IGFBP2).