Skip to main content
. 2020 Jul 23;5(14):e135317. doi: 10.1172/jci.insight.135317

Figure 5. Fibrinogen and fibronectin have the most numerous internal cleavages in vegetations.

Figure 5

(A) Pie chart of 100 proteins with the most internal N-termini (top 15 are named) shows that fibrinogen (FGA, FGB, FGG) and fibronectin (FN1) have the most numerous internal cleavages in vegetations. (B) The top 15 most cleaved proteins (from left to right) and their average abundance was compared with overall average protein abundance (dotted red line). (C) Number of internal N-termini identified in the top 15 most abundant proteins from the shotgun analysis. (D) Pearson correlation plot shows a modest positive correlation (significantly non-0 P < 0.0001) between protein abundance and number of internal N-termini. The top 15 most abundant proteins are labeled with their gene symbols.