Table 2.
Synthesis of various model acyl sulfonamides using [11C]CO carbonylation chemistry
 | |||||
|---|---|---|---|---|---|
| Entry | Product | Aryl halide | TE (%) | RCP (%) | RCY (%) |
| 1 | [11C]2 | Iodobenzene | 98.6 ± 1 | 97.6 ± 3 | 96.2 ± 3 |
| 2 | [11C]2 | Bromobenzene | 70.8 ± 11 | 89.5 ± 4 | 63.4 ± 11 |
| 3 | [11C]3 | 1-Iodo-4-methoxybenzene | 99.9 ± 0 | 98.3 ± 1 | 98.2 ± 1 |
| 4 | [11C]4 | 1-Iodonaphthalene | 82.1 ± 4 | 99.8 ± 0 | 81.3 ± 4 |
| 5 | [11C]5 | 1-Bromo-4-chlorobenzene | 85.1 ± 7 | 95.1 ± 0 | 81.0 ± 6 |
| 6 | [11C]6 | 1-Bromo-4-iodobenzene | 90.1 ± 3 | 99.9 ± 0 | 90.0 ± 3 |
| 7 | [11C]7 | 4-Iodobenzonitrile | 80.7 ± 14 | 98.3 ± 1 | 79.4 ± 14 |
| 8 | [11C]8 | 1-Iodo-4-(trifluoromethyl)benzene | 83.6 ± 6 | 98.5 ± 1 | 82.3 ± 7 |
| 9 | [11C]9 | 4-Iodonitrobenzene | 72.2 ± 1 | 86.5 ± 1 | 62.4 ± 1 |
| 10 | [11C]10 | Ethyl 4-iodobenzoate | 90.0 ± 5 | 93.7 ± 3 | 84.2 ± 4 |
| 11 | [11C]11 | tert-Butyl(4-iodophenyl)carbamate | 97.1 ± 2 | 81.3 ± 1 | 79.0 ± 1 |
| 12 | [11C]l2 | 3-Iodothiophene | 99.6 ± 0 | 99.0 ± 0 | 98.6 ± 0 |
| 13 | [11C]l3 | 4-Iodo-toluene | 98.2 ± 1 | 93.1 ± 1 | 91.5 ± 2 |
| 14 | [11C]14 | 4-Iodo-toluene | 97.7 ± 2 | 75.8 ± 6 | 74.1 ± 8 |
| 15 | [11C]15 | 4-Iodo-toluene | 98.6 ± 1 | 92.7 ± 4 | 91.4 ± 4 |
| 16 | [11C]16 | Bromobenzene | 72.7 ± 8 | 73.6 ± 21 | 57.0 ± 17 |
| 17 | [11C]16 | Iodobenzene | 96.5 ± 3 | 99.5 ± 1 | 96.0 ± 2 |
The position of the carbon-11 label is depicted with *.