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. 2020 Aug 27;2(3):zcaa018. doi: 10.1093/narcan/zcaa018

Figure 4.

Figure 4.

Pioneer transcription factors are recruited to the HOXB13 regulatory region. Meta-analysis of publicly available chromatin immunoprecipitation sequencing (GSE56288) to probe AR, FOXA1 and HOXB13 binding has revealed occupancy of these factors at the HOXB13 transcription start site and 3′ exon 2 in human prostate tumors and in prostate cell lines expressing all three factors. Two BRD4-binding sites, BRAH1 and BRAH2 (BRD4 recruitment site at HOXB13), are present at nucleotides 268 and 799 upstream of the HOXB13 transcription start site.