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. 2020 Aug 27;2(3):zcaa018. doi: 10.1093/narcan/zcaa018

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© The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — HOXB13 may compensate for CHD1 deficiency, thus promoting chromatin accessibility. CHD1 regulates the binding of AR and consequently differentiation through promoting the expression of the canonical AR transcriptome. In CHD1-deficient conditions, AR enhancers are enriched in HOXB13 binding and HOX motifs. CHD1 deficiency in tumor cells is associated with a diversion of AR binding toward a malignant program likely mediated by the activation of HOXB13 transcriptional network. Figure was created with www.biorender.com.