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. Author manuscript; available in PMC: 2020 Aug 28.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2010;11:65–89. doi: 10.1146/annurev-genom-082509-141523

Figure 3.

Figure 3

Schematic of the pattern of chromosomal admixture around a disease locus. We suppose the disease is inherited from the majority ancestry population (dark green), with the minority ancestry population shown in light green. The graphs show the percentage of ancestry derived from the dark green segment of chromosome. (a) In the region of the disease locus (yellow bar), there is an excess of majority ancestry blocks among cases, revealed as a spike in a graph of average ancestry for cases along the chromosome. The orange bar indicates the location of the disease gene. (b) Among population controls, the distribution of ancestry blocks is random across the chromosome. The spike of ancestry can be quantified either by comparing case ancestry with control ancestry at the same location or by comparing peak case ancestry with average case ancestry across all chromosomes.