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. Author manuscript; available in PMC: 2020 Aug 28.
Published in final edited form as: J Alzheimers Dis. 2020;76(4):1215–1242. doi: 10.3233/JAD-200282

Fig. 2.

Fig. 2.

Transport of lead (Pb), cadmium (Cd) and manganese (Mn) to the brain. Lead, cadmium and manganese enter the body through the gut and lung and are distributed in the bloodstream and transported to the brain. Cadmium and manganese also reach the brain through the olfactory nervous system. Lead crosses the blood-brain barrier and accumulates in the brain. All three metals can accumulate in the choroid plexus, a component of the blood-CSF (cerebrospinal fluid) barrier. The image was created in the Mind the GRAPH (https://mindthegraph.com/).