Table 1.

PICOS criteria for inclusion and exclusion of studies

Parameter	Inclusion criteria	Exclusion criteria
Patients	Children (defifined as age 0 to 18 years) and adults with OI diagnosed using accepted diagnostic criteria, based on clinical or laboratory findings, or both. Individuals affected with all types of OI are included in this review.	Randomized controlled trials in which any enrolled patients who receive the bisphosphonate therapy using IV administration
Intervention	Oral Bisphosphonate
Comparator	Placebo
Outcomes	Bone mineral density as measured by dual‐energy X‐ray absorptiometry (DEXA), decreased fracture incidence, change in biochemical markers of bone and mineral metabolism, bone histology, growth, bone pain, quality of life and others were assessed	Studies without defined clinical outcomes
Study design	Randomized controlled trials	Non‐randomized controlled trials; Retrospective, prospective, or concurrent cohort studies; Cross sectional studies