Table 2.
Diagnostic Performance for Predicting Overall Survival
| Diagnostic Performance for Predicting Death | ||||
|---|---|---|---|---|
| 2-year AUROC (n=7849) | 5-year AUROC (n=6891) | 10-year AUROC (n=4029) | Cox PH Model Concordance | |
| Clinical Parameters | ||||
| FRS | 0.700 | 0.688 | 0.693 | 0.681 |
| BMI | 0.546 | 0.499 | 0.533 | 0.520 |
| Automated CT Biomarkers | ||||
| Univariate | ||||
| AoCa (Ag) | 0.746 | 0.743* | 0.746* | 0.735 |
| Muscle HU | 0.736 | 0.721 | 0.717 | 0.700 |
| V/S Fat Ratio | 0.685 | 0.661 | 0.656 | 0.648 |
| Liver HU | 0.644 | 0.619 | 0.628 | 0.602 |
| L1 HU | 0.627 | 0.646 | 0.640 | 0.637 |
| Multivariate** | ||||
| AoCa + Muscle | 0.780 | 0.768 | 0.768 | 0.772 |
| AoCa + Muscle + Liver | 0.811 | 0.782 | 0.777 | 0.778 |
| AoCa + Muscle + Liver + V/S | 0.817 | 0.789 | 0.780 | 0.780 |
| AoCa + FRS° | 0.774 | 0.744 | 0.746 | 0.733 |
| AoCa+Muscle+Liver+V/S+FRS° | 0.847 | 0.796 | 0.792 | 0.778 |
Cox PH model = Cox proportional hazards model; AUROC = area under the ROC curve; FRS = Framingham Risk Score; BMI = body mass index; AoCa = aortic calcification; Ag = Agatston score; HU = Hounsfield units; V/S = visceral-to-subcutaneous
*
p<0.05 compared with FRS performance
**
p<0.05 compared with FRS performance
°
No significant improvement compared with CT-based performance without FRS (p=0.509–0.965 for AoCa comparison and p=0.406–0.806 for AoCa+Muscle+Liver+V/S comparison)