. Author manuscript; available in PMC: 2020 Aug 28.

Published in final edited form as: New Horiz Transl Med. 2016 Dec 10;3(5):224–232.

Table 2.

TAC3 pathway based on gene-gene expression correlations at 108 SCZ risk loci

Gene	Isoform	TAC3 (ρ)	# COR	Locus	SNP
CA14	219464_at	0.876	39	chr1:149998890–150242490	rs140505938
OTUD7B	1555139_a_at	0.778	21	chr1:149998890–150242490	rs140505938
OTUD7B	229488_at	0.69	21	chr1:149998890–150242490	rs140505938
EFHD1	209343_at	0.863	42	chr2:233559301–233753501	rs6704768
PCGEM1	234515_at	0.763	25	chr2:193848340–194028340	rs59979824
BOLL	236954_at	0.692	18	chr2:198148577–198835577	rs6434928
NT5DC2 [33]	1556895_a_at	0.752	25	chr3:52541105–52903405	rs2535627
C3orf49	1553805_at	0.69	5	chr3:63792650–64004050	rs832187
FXR1^* [33]	1569171_a_at	0.683	7	chr3:180588843–181205585	rs9841616
NISCH	201591_s_at	−0.753	15	chr3:52541105–52903405	rs2535627
GPM6A [33]	236024_at	0.757	27	chr4:176851001–176875801	rs1106568
NEK1 [33]	216213_at	0.689	5	chr4:170357552–170646052	rs10520163
NDUFA2	222971_at	0.734	12	chr5:140023664–140222664	chr5_140143664_I
GFRA3 [33]	214479_at	0.708	12	chr5:137598121–137948092	rs3849046
HCG22	1560767_at	0.87	40	chr6:28303247–28712247	rs115329265
HFE	210864_x_at	0.847	38	chr6:28303247–28712247	rs115329265
	211863_x_at	0.778
	206086_x_at	0.75
	211866_x_at	0.736
	211332_x_at	0.692
EHMT2	229079_at	0.803	30	chr6:28303247–28712247	rs115329265
PFDN6	242048_at	0.758	21	chr6:28303247–28712247	rs115329265
PFDN6	222019_at	0.755	21	chr6:28303247–28712247	rs115329265
HLADOA	217001_x_at	0.717	13	chr6:28303247–28712247	rs115329265
PTN^*	208408_at	0.841	41	chr7:137039644–137085244	rs3735025
PTN^*	209466_x_at	0.792	41	chr7:137039644–137085244	rs3735025
MPP6 [33]	205429_s_at	−0.69	11	chr7:24619494–24832094	chr7_24747494_D
TSNARE1	1552799_at	0.778	19	chr8:143309503–143330533	rs4129585
TLE1^*	203220_s_at	0.738	27	chr9:84630941–84813641	rs11139497
CYP17A1	205502_at	0.778	25	chr10:104423800–105165583	rs55833108
CNNM2 [33]	1554523_a_at	0.7	7	chr10:104423800–105165583	rs55833108
CHRM4	221357_at	0.851	36	chr11:46342943–46751213	chr11_46350213_D
LUZP2	215323_at	0.826	37	chr11:24367320–24412990	rs11027857
ARHGAP1	216689_x_at	0.783	37	chr11:46342943–46751213	chr11_46350213_D
CREB3L1	213059_at	0.78	23	chr11:46342943–46751213	chr11_46350213_D
CLP1	1566151_at	0.778	33	chr11:57386294–57682294	rs9420
CTNND1 [33]	1557944_s_at	0.757	35	chr11:57386294–57682294	rs9420
DRD2 ^*	206590_x_at	0.754	12	chr11:113317794–113423994	rs2514218
DGKZ	239342_at	0.682	8	chr11:46342943–46751213	chr11_46350213_D
PITPNM2	1552923_a_at	0.736	23	chr12:123448113–123909113	rs2851447
TMTC1	224397_s_at	0.699	4	chr12:29905265–29940365	rs679087
MPHOSPH9 [33]	221965_at	−0.781	20	chr12:123448113–123909113	rs2851447
RGS6 [31]	214538_x_at	0.684	8	chr14:72417326–72450526	rs2332700
KLC1	212878_s_at	−0.782	26	chr14:103996234–104184834	rs12887734
CHRNA3^*	210221_at	0.834	44	chr15:78803032–78926732	rs8042374
CHRNA3^*	211587_x_at	0.829	44	chr15:78803032–78926732	rs8042374
GRIN2A^* [31]	206534_at	0.768	28	chr16:9875519–9970219	rs9922678
ASPHD1	1553997_a_at	0.761	23	chr16:29924377–30144877	rs12691307
ERCC4	210158_at	0.692	5	chr16:13728459–13761359	rs7405404
NFATC3 [33]	225139_at	−0.73	40	chr16:67709340–68311340	rs8044995
	210555_s_at	−0.785
	207416_s_at	−0.825
MYO15A	220288_at	0.774	30	chr17:17722402–18030202	rs8082590
TOM1L2	214840_at	0.682	2	chr17:17722402–18030202	rs8082590
CILP2	1552289_a_at	0.812	31	chr19:19374022–19658022	rs2905426
HAPLN4	235420_at	0.77	35	chr19:19374022–19658022	rs2905426
TM6SF2	234092_s_at	0.759	22	chr19:19374022–19658022	rs2905426
GATAD2A [33]	222526_at	−0.693	13	chr19:19374022–19658022	rs2905426
SUGP1	215004_s_at	−0.701	12	chr19:19374022–19658022	rs2905426
KCNB1^* [31]	231053_at	0.788	13	chr20:48114136–48131649	rs7267348
PTGIS [33]	208131_s_at	0.763	6	chr20:48114136–48131649	rs7267348
SEPT3	223362_s_at	0.839	26	chr22:42315744–42689414	rs6002655
TCF20	215511_at	0.839	39	chr22:42315744–42689414	rs6002655
TCF20	238667_at	0.803	39	chr22:42315744–42689414	rs6002655
TNFRSF13C	1552892_at	0.826	37	chr22:42315744–42689414	rs6002655
CYP2D6	215809_at	0.706	6	chr22:42315744–42689414	rs6002655

From top 10% of significant correlations (ρ ≥│0.682│). chr=chromosome.

TAC3 isoform (219992_at) correlations between genes. ρ =correlations; # other genes= the number of correlations with other genes; Bold= four genes implicated in the DRD2 pathway

= seven known genes implicated in SCZ etiology or treatment before the 2014 GWAS study came out; Italics=12 genes cited in the literature that reference the 2014 GWAS study.[5]