Table 3.
Novel Pathway based on correlated gene-gene expression
| Gene 1 | Isoform 1 | Locus | SNP | Gene 2 | Isoform 2 | Correlation | Locus | SNP |
|---|---|---|---|---|---|---|---|---|
| CNOT1 | 1554052_at | *chr16 | rs12325245 | DDX28 | 203785_s_at | 0.514 | #chr16 | rs8044995 |
| CNOT1 | 200860_s_at | *chr16 | rs12325245 | GFOD2 | 221028_s_at | 0.525 | #chr16 | rs8044995 |
| CNOT1 | 1554052_at | *chr16 | rs12325245 | GNL3 | 217850_at | 0.522 | chr3 | rs2535627 |
| CNOT1 | 200860_s_at | *chr16 | rs12325245 | GNL3 | 217850_at | 0.641 | chr3 | rs2535627 |
| CNOT1 | 1554052_at | *chr16 | rs12325245 | PBRM1 | 224152_s_at | 0.539 | chr3 | rs2535627 |
| CNOT1 | 1554052_at | *chr16 | rs12325245 | SHMT2 | 214096_s_at | 0.537 | #chr12 | rs12826178 |
| CNOT1 | 1554052_at | *chr16 | rs12325245 | SHMT2 | 214095_at | 0.549 | #chr12 | rs12826178 |
| CNOT1 | 1554052_at | *chr16 | rs12325245 | SHMT2 | 214437_s_at | 0.575 | #chr12 | rs12826178 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | HSPA9 | 200691_s_at | 0.509 | *chr5 | rs3849046 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | HSPA9 | 200692_s_at | 0.503 | *chr5 | rs3849046 |
| DDX28 | 214025_at | #chr16 | rs8044995 | HSPA9 | 200692_s_at | -0.523 | *chr5 | rs3849046 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | IMMP2L | 227153_at | 0.534 | chr7 | rs13240464 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | L3MBTL2 | 1555815_a_at | 0.508 | chr22 | rs9607782 |
| DDX28 | 40255_at | #chr16 | rs8044995 | L3MBTL2 | 1555815_a_at | 0.508 | chr22 | rs9607782 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | L3MBTL2 | 1555815_a_at | 0.533 | chr22 | rs9607782 |
| DDX28 | 40255_at | #chr16 | rs8044995 | OGFOD2 | 219245_s_at | 0.578 | *chr12 | rs2851447 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | OGFOD2 | 219245_s_at | 0.587 | *chr12 | rs2851447 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | OGFOD2 | 219245_s_at | 0.655 | *chr12 | rs2851447 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | OGFOD2 | 219246_s_at | 0.604 | *chr12 | rs2851447 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | OGFOD2 | 44617_at | 0.535 | *chr12 | rs2851447 |
| DDX28 | 40255_at | #chr16 | rs8044995 | OGFOD2 | 44617_at | 0.573 | *chr12 | rs2851447 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | OGFOD2 | 44617_at | 0.607 | *chr12 | rs2851447 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | SHMT2 | 214095_at | 0.590 | #chr12 | rs12826178 |
| DDX28 | 40255_at | #chr16 | rs8044995 | SHMT2 | 214095_at | 0.632 | #chr12 | rs12826178 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | SHMT2 | 214095_at | 0.719 | #chr12 | rs12826178 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | SHMT2 | 214096_s_at | 0.586 | #chr12 | rs12826178 |
| DDX28 | 40255_at | #chr16 | rs8044995 | SHMT2 | 214096_s_at | 0.667 | #chr12 | rs12826178 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | SHMT2 | 214096_s_at | 0.699 | #chr12 | rs12826178 |
| DDX28 | 203784_s_at | #chr16 | rs8044995 | SHMT2 | 214437_s_at | 0.509 | #chr12 | rs12826178 |
| DDX28 | 214025_at | #chr16 | rs8044995 | SHMT2 | 214437_s_at | -0.537 | #chr12 | rs12826178 |
| DDX28 | 40255_at | #chr16 | rs8044995 | SHMT2 | 214437_s_at | 0.703 | #chr12 | rs12826178 |
| DDX28 | 203785_s_at | #chr16 | rs8044995 | SHMT2 | 214437_s_at | 0.751 | #chr12 | rs12826178 |
| GFOD2 | 221028_s_at | #chr16 | rs8044995 | GNL3 | 217850_at | 0.515 | chr3 | rs2535627 |
| GFOD2 | 221028_s_at | #chr16 | rs8044995 | L3MBTL2 | 223205_s_at | 0.532 | chr22 | rs9607782 |
| GFOD2 | 221028_s_at | #chr16 | rs8044995 | SHMT2 | 214096_s_at | 0.542 | #chr12 | rs12826178 |
| GFOD2 | 221028_s_at | #chr16 | rs8044995 | SHMT2 | 214095_at | 0.601 | #chr12 | rs12826178 |
| GNL3 | 217850_at | chr3 | rs2535627 | HSPA9 | 200691_s_at | 0.605 | *chr5 | rs3849046 |
| GNL3 | 217850_at | chr3 | rs2535627 | HSPA9 | 200692_s_at | 0.527 | *chr5 | rs3849046 |
| GNL3 | 217850_at | chr3 | rs2535627 | SHMT2 | 214095_at | 0.545 | #chr12 | rs12826178 |
| GNL3 | 217850_at | chr3 | rs2535627 | SHMT2 | 214096_s_at | 0.521 | #chr12 | rs12826178 |
| GNL3 | 217850_at | chr3 | rs2535627 | SHMT2 | 214437_s_at | 0.565 | #chr12 | rs12826178 |
| HSPA9 | 200691_s_at | *chr5 | rs3849046 | L3MBTL2 | 1555815_a_at | 0.515 | chr22 | rs9607782 |
| HSPA9 | 200690_at | *chr5 | rs3849046 | SHMT2 | 214096_s_at | 0.508 | #chr12 | rs12826178 |
| HSPA9 | 200690_at | *chr5 | rs3849046 | SHMT2 | 214437_s_at | 0.579 | #chr12 | rs12826178 |
| HSPA9 | 200691_s_at | *chr5 | rs3849046 | SHMT2 | 214095_at | 0.674 | #chr12 | rs12826178 |
| HSPA9 | 200691_s_at | *chr5 | rs3849046 | SHMT2 | 214096_s_at | 0.686 | #chr12 | rs12826178 |
| HSPA9 | 200691_s_at | *chr5 | rs3849046 | SHMT2 | 214437_s_at | 0.756 | #chr12 | rs12826178 |
| HSPA9 | 200692_s_at | *chr5 | rs3849046 | SHMT2E | 214095_at | 0.652 | #chr12 | rs12826178 |
| HSPA9 | 200692_s_at | *chr5 | rs3849046 | SHMT2 | 214096_s_at | 0.607 | #chr12 | rs12826178 |
| HSPA9 | 200692_s_at | *chr5 | rs3849046 | SHMT2 | 214437_s_at | 0.762 | #chr12 | rs12826178 |
| HSPA9 | 200690_at | *chr5 | rs3849046 | WDR55 | 223833_at | 0.507 | #chr5 | chr5_140143664_I |
| HSPA9 | 200691_s_at | *chr5 | rs3849046 | WDR55 | 223833_at | 0.537 | #chr5 | chr5_140143664_I |
| HSPA9 | 200692_s_at | *chr5 | rs3849046 | WDR55 | 223833_at | 0.535 | #chr5 | chr5_140143664_I |
| IMMP2L | 227153_at | chr7 | rs13240464 | OGFOD2 | 219245_s_at | 0.576 | *chr12 | rs2851447 |
| IMMP2L | 227153_at | chr7 | rs13240464 | OGFOD2 | 44617_at | 0.532 | *chr12 | rs2851447 |
| IMMP2L | 227153_at | chr7 | rs13240464 | SHMT2 | 214095_at | 0.586 | #chr12 | rs12826178 |
| IMMP2L | 227153_at | chr7 | rs13240464 | SHMT2 | 214096_s_at | 0.569 | #chr12 | rs12826178 |
| IMMP2L | 227153_at | chr7 | rs13240464 | SHMT2 | 214437_s_at | 0.522 | #chr12 | rs12826178 |
| L3MBTL2 | 1555815_a_at | chr22 | rs9607782 | OGFOD2 | 219245_s_at | 0.599 | *chr12 | rs2851447 |
| L3MBTL2 | 1555815_a_at | chr22 | rs9607782 | OGFOD2 | 44617_at | 0.638 | *chr12 | rs2851447 |
| L3MBTL2 | 223205_s_at | chr22 | rs9607782 | OGFOD2 | 219245_s_at | 0.511 | *chr12 | rs2851447 |
| L3MBTL2 | 1555815_a_at | chr22 | rs9607782 | SHMT2 | 214095_at | 0.661 | #chr12 | rs12826178 |
| L3MBTL2 | 1555815_a_at | chr22 | rs9607782 | SHMT2 | 214096_s_at | 0.634 | #chr12 | rs12826178 |
| L3MBTL2 | 1555815_a_at | chr22 | rs9607782 | SHMT2 | 214437_s_at | 0.595 | #chr12 | rs12826178 |
| L3MBTL2 | 223205_s_at | chr22 | rs9607782 | SHMT2 | 214095_at | 0.544 | #chr12 | rs12826178 |
| L3MBTL2 | 223205_s_at | chr22 | rs9607782 | SHMT2 | 214096_s_at | 0.545 | #chr12 | rs12826178 |
| OGFOD2 | 219245_s_at | *chr12 | rs2851447 | SHMT2 | 214095_at | 0.794 | #chr12 | rs12826178 |
| OGFOD2 | 219245_s_at | *chr12 | rs2851447 | SHMT2 | 214096_s_at | 0.750 | #chr12 | rs12826178 |
| OGFOD2 | 219245_s_at | *chr12 | rs2851447 | SHMT2 | 214437_s_at | 0.736 | #chr12 | rs12826178 |
| OGFOD2 | 219246_s_at | *chr12 | rs2851447 | SHMT2 | 214095_at | 0.645 | #chr12 | rs12826178 |
| OGFOD2 | 219246_s_at | *chr12 | rs2851447 | SHMT2 | 214096_s_at | 0.536 | #chr12 | rs12826178 |
| OGFOD2 | 219246_s_at | *chr12 | rs2851447 | SHMT2 | 214437_s_at | 0.569 | #chr12 | rs12826178 |
| OGFOD2 | 44617_at | *chr12 | rs2851447 | SHMT2 | 214095_at | 0.748 | #chr12 | rs12826178 |
| OGFOD2 | 44617_at | *chr12 | rs2851447 | SHMT2 | 214096_s_at | 0.754 | #chr12 | rs12826178 |
chr=chromosome; chr3=chr3:52541105–52903405; *chr5= chr5:137598121–137948092; #chr5= chr5:140023664–140222664; chr7=chr7:110843815–111205915; *chr12= chr12:123448113–123909113; #chr12= chr12:57428314–57682971; *chr16= chr16:58669293–58682833; #chr16= chr16:67709340–68311340; chr22= chr22:41408556–41675156. Italics= six genes cited by Bimbaum et al. 2015 that reference the 2014 GWAS study. [33] Correlations (rho (ρ)=≥│0.5│) excluding: 1) the 35 genes previously implicated in schizophrenia; [5] 2) genes not correlated with genes previously implicated in schizophrenia;