Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 27;8(2):e000881. doi: 10.1136/jitc-2020-000881

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Five-color immunohistochemical multiplex analysis of stage II CRCs based on pole and MSI status. (A) Comparisons of cell proportion of immune cells (CD8+, CD45RO+, CD8 +CD45RO+, CD3+, CD3 +PD-1+ and CD8+PD-L1+) between pole EDMs and pole wild type or non-EDMs (panel 1). (B) Comparisons of cell proportion of immune cells (CD4+, CD68+, PD-L1+, CD68+CD163-, CD68+CD163+, CD68+PD-L1+ and CD+FOXP3+) between pole EDMs and pole wild-type or non-EDMs (panel 2). (C) Comparisons of cell proportion of immune cells (CD8+, CD45RO+ and CD8+CD45RO+) between pole EDMs, MSI-H and MSS. (D) Representative immunohistochemical multiplex images of CD8+, CD45RO+ and CD8+CD45RO+ in POLE EDMs, MSI-H and MSS tumors. *P<0.05, **P<0.01, ***P<0.001. CRCs, colorectal cancer; EDMs, exonuclease domain mutations; MSI-H, microsatellite instability-high; MSS, microsatellite stable.