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. 2020 Aug 27;8(2):e001141. doi: 10.1136/jitc-2020-001141

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Distributions of potential biomarkers in NR and R in (A). Atezolizumab monotherapy (B). Combination therapy. (i) Tumor growth rate; (ii) TMB; (iii) ieff density in tumor; (iv) Teff/Treg ratio in tumor; (v) PD-L1 expression in cancer cells; (vi). PD-L1 expression in APCs; (vii) PD-1 expression in teff; (viii) Cross-arm binding efficiency χ of atezolizumab; (ix) CEA expression in cancer cells; (x) Cross-arm binding efficiency λ of cibisatamab; (xi) CD3 expression in teff; (xii) CD3-cibisatamab binding affinity. APCs, antigen-presenting cells; CEA, carcinoembryonic antigen; NS, not significant; PD1, programmed cell death protein 1; PD-L1, PD-ligand 1; TMB, tumor mutational burden. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, **** P ≤ 0.0001.