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. 2020 Aug 27;8(2):e001141. doi: 10.1136/jitc-2020-001141

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Distributions of potential biomarkers in ROA, ROB, ROC, ROCMB and NR. (A) TMB; (B) teff density in tumor; (C) Teff/Treg ratio in tumor; (D) PD-L1 expression in cancer cells; (E) CEA expression in cancer cells; (F) Cross-arm binding efficiency λ of cibisatamab. CEA, carcinoembryonic antigen; NR, non-responder; NS, not significant; PD-L1, programmed cell death ligand 1; ROA, responder to atezolizumab monotherapy; ROB, responder to both monotherapies; ROC, responder to cibisatamab monotherapy; ROCMB, responder to combination therapy; TMB, tumor mutational burden. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, **** P ≤ 0.0001.