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. 2020 Aug 19;3(3):205–212. doi: 10.1093/abt/tbaa020

Figure 1.

Figure 1

Analysis of targets and formats of the therapeutics under development for COVID-19. (A) Targets of therapeutic antibodies under development for treating COVID-19. SARS-CoV-2 represents the targets that are SARS-CoV-2 virus specific but unspecified. Only the top five targets by amounts are shown, the rest were populated in “Others,” such as IL-1, IL-12, IL-17, C5, C5a, PD-1, 4-1BB, P-selectin, etc. (B) The formats for therapeutics under development for treating COVID-19. MAb represents the conventional full-length IgG, including the chimeric Abs. Polyclonal Abs represents purified polyclonal Abs from immunized transgenic animals or transiently transfected cells, which originally derived from swine, transgenic cow, ostrich, avian and human. “Others” include one non-antibody recombinant protein (rhACE2), and DARPin, mRNA-encoding mAb and radiotherapeutic formats. The number of programs for each target and format are shown, followed by the proportion to the total number of all programs in paraphrase. Figure 1 is based on “Tracker” data as of 8 August 2020.