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. 2020 May 11:bbaa079. doi: 10.1093/bib/bbaa079

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© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Investigative flowcharts for prioritization of biotargets and signaling pathways of VC action against sepsis through a systematic network pharmacology approach. All the reported genes/targets of VC and sepsis were screened and identified using databases available online prior to harvesting the antisepsis targets of VC. After the construction of a PPI network and identification of the hub targets of VC against sepsis, the biological processes and KEGG signaling pathways were determined. A network of VC-target-GO-KEGG-sepsis was visualized following bioinformatics analysis.