Table 3.
Gene ontological features associated with the shared dysregulated genes
| Terms | Pathways | Adj. P-value * | Associated genes |
|---|---|---|---|
| DRA | |||
| GO:0033674 | Positive regulation of kinase activity | 1.35 × 10−4 | CD74, TRAF4, MET |
| GO:0070372 | Regulation of ERK1 and ERK2 cascade | 1.32 × 10−3 | CD74, BRAF, MET, ZFP36L2 |
| GO:0000165 | MAPK cascade | 1.86 × 10−3 | BRAF, MET, ZFP36L2, CD74 |
| GO:0071277 | Cellular response to calcium ion | 3.71 × 10−2 | BRAF |
| GO:0035023 | Regulation of Rho protein signal transduction | 5.01 × 10−2 | MET |
| HP:0002020 | Gastroesophageal reflux | 3.98 × 10−2 | BRAF |
| SHOB | |||
| GO:0070296 | Sarcoplasmic reticulum calcium ion transport | 6.73 × 10−3 | ATP2A2 |
| GO:0042058 | Regulation of epidermal growth factor receptor signaling pathway | 4.26 × 10−2 | CDC42 |
| GO:0030544 | Hsp70 protein binding | 2.01 × 10−2 | SPN |
| GO:0008009 | Chemokine activity | 3.39 × 10−2 | CKLF |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | 3.54 × 10−2 | CRYAB |
| HP:0002878 | Respiratory failure | 4.26 × 10−2 | CRYAB |
| PNA | |||
| GO:2000665 | Regulation of interleukin-10/13 secretion | 6.28 × 10−3 | TNFRSF21 |
| GO:0071345 | Cellular response to cytokine stimulus | 1.15 × 10−2 | SOCS3, BCL6, TNFRSF21 |
| GO:0006954 | Inflammatory response | 2.84 × 10−2 | LTB4R, TNFRSF21 |
| GO:0046426 | Negative regulation of JAK-STAT cascade | 4.82 × 10−2 | SOCS3 |
| GO:0004974 | Leukotriene receptor activity | 6.28 × 10−3 | LTB4R |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | 4.92 × 10−2 | PLEKHG5 |
| SARS | |||
| GO:0043068 | Positive regulation of programmed cell death | 1.54 × 10−4 | BCL6, GADD45A, CASP2, FOXO3, PPID |
| GO:0071345 | Cellular response to cytokine stimulus | 2.05 × 10−3 | EGR1, IL1RN, BCL6, FOXO3, TNFRSF21 |
| GO:0034599 | Cellular response to oxidative stress | 2.22 × 10−2 | ANKRD2, FOXO3 |
| GO:1900744 | Regulation of p38MAPK cascade | 5.08 × 10−2 | GADD45A |
| GO:0042345 | Regulation of NF-κB import into nucleus | 5.08 × 10−2 | NFKBIA |
| GO:0019901 | Protein kinase binding | 5.01 × 10−5 | PPP1R15A, CALM3, ANKRD2, FOXO3, PDLIM5, CALM1, CALM2 |
| HP:0006530 | Interstitial pulmonary disease | 2.18 × 10−2 | IL1RN |
*Pathways that are highly relevant to the respective conditions and have adjusted P-value ≤0.05 were considered.
Abbreviations: DRA, diarrhea; PNA, pneumonia; SHOB, shortness of breath; and SARS, severe acute respiratory syndrome.