Table 3.
Mantel-Cox Rate Ratios for Time Clinical Recovery, Improvement, or Discharge
| Remdesivir vs Supportive Care Rate Ratio (95% Confidence Interval) | |||
|---|---|---|---|
| Stratification Subgroup | Time to Recovery | Time to Clinical Improvement | Time to Discharge |
| Sex | |||
| Male | 0.83 (0.56–1.22) | 0.82 (0.56–1.21) | 0.85 (0.58–1.26) |
| Female | 1.48 (0.83–2.63) | 1.50 (0.85–2.64) | 1.38 (0.76–2.52) |
| Age group | |||
| 18–49 y | 1.17 (0.61–2.21) | 1.02 (0.54–1.93) | 1.13 (0.59–2.13) |
| 50–64 y | 0.95 (0.57–1.56) | 0.94 (0.57–1.54) | 0.93 (0.56–1.54) |
| ≥65 y | 0.96 (0.55–1.69) | 1.06 (0.60–1.87) | 1.01 (0.55–1.83) |
| Race | |||
| Black or African American | 2.12 (0.85–5.28) | 1.67 (0.68–4.08) | 2.29 (0.94–5.57) |
| Hispanic or Latino | 0.82 (0.51–1.33) | 0.76 (0.47–1.24) | 0.72 (0.44–1.18) |
| White or Caucasian | 1.14 (0.66–1.97) | 1.19 (0.68–2.07) | 1.27 (0.73–2.24) |
| Other | 0.37 (0.08–1.63) | 0.18 (0.03–1.06) | 0.36 (0.07–1.69) |
| Oxygen requirementsa | |||
| IMV | 0.93 (0.40–2.14) | 0.93 (0.42–2.07) | 1.07 (0.44–2.61) |
| NIPPV or HFOD | 0.87 (0.44–1.70) | 0.97 (0.50–1.87) | 0.86 (0.44–1.69) |
| Low-flow oxygen | 1.06 (0.67–1.68) | 1.04 (0.67–1.63) | 1.03 (0.66–1.69) |
| Room air | 1.30 (0.30–5.67) | 1.18 (0.32–4.36) | 1.18 (0.32–4.36) |
| Days from symptoms onseta | |||
| <7 d | 1.26 (0.83–1.92) | 1.18 (0.77–1.79) | 1.24 (0.81–1.90) |
| ≥7 d | 0.76 (0.46–1.26) | 0.82 (0.50–1.34) | 0.71 (0.42–1.18) |
Abbreviations: HFNC, high-flow nasal cannula; HFOD, high-flow oxygen devices; IMV, invasive mechanical ventilation; NIPPV, noninvasive positive pressure ventilation.
aOn admission, IMV, NIPPV, HFNC.