Table 1.
Systematic Review of COVID-19 in Pregnancy and the Peripartum Period
| Total No. of Cases (n = 11 308) | No. (%) |
|---|---|
| Estimated gestational age (n = 2824)a | |
| 1st trimester (1–12 wk) | 66 (2) |
| 2nd trimester (13–27 wk) | 574 (20) |
| 3rd trimester (>28 wk) | 2184 (77) |
| Symptoms (n = 11 308) | |
| Cough | 2704 (24) |
| Fever | 2051 (18) |
| Fatigue, malaise, myalgias | 1525 (13) |
| Headache | 1448 (13) |
| Shortness of breath, dyspnea | 1391 (12) |
| Otherb | 4120 (36) |
| Asymptomatic | 366 (3) |
| Severity (as defined by authors; n = 1999) | |
| Mild–moderatec | 1583 (79) |
| Severe/ICU | 416 (21) |
| Investigational treatment reported (n = 184)d | |
| Hydroxychloroquine | 106 (58) |
| Lopinavir/ritonavir | 39 (21) |
| Remdesivir | 13 (7) |
| IL-1, IL-6 inhibitors | 13 (7) |
| IVIG or gamma globulin | 9 (5) |
| Convalescent plasma | 4 (2) |
| Maternal outcomes (n = 10 597) | |
| Alive to delivery | 10 437 (98) |
| Died | 33 (0.3) |
| Still hospitalized | 127 (1.0) |
| Pregnancy outcomes (n = 2297) | |
| Live births | 1375 (60) |
| In utero, pregnancy ongoing | 869 (38) |
| Spontaneous miscarriage (<20 wk) | 20 (0.9) |
| Elective abortion | 17 (0.7) |
| Stillbirth (>20 wk) | 14 (0.6) |
| Ectopic pregnancy | 2 (0.08) |
| Gestational age at birth (n = 868) | |
| Term | 695 (80) |
| Preterm (<37 wk) | 173 (20) |
| Delivery type (n = 871) | |
| Vaginal delivery | 259 (30) |
| Cesarean section | 612 (70) |
| Neonatal outcomes (n = 1163) | |
| Alive | 1155 (99) |
| Neonatal death | 8 (0.7) |
Abbreviations: ICU, intensive care unit; IL, interleukin; IVIG, intravenous immunoglobulin.
aOne large cohort study (n = 8207) did not have estimated gestational ages available.
bOther symptoms included diarrhea (n = 596), nausea/vomiting (n = 700), sore throat (n = 1005), loss of taste or smell (n = 803), and chills (n = 1016).
cIncluded asymptomatic cases.
dTreatment received at any time during pregnancy or postpartum after the time of COVID-19 diagnosis. Some women may have received multiple treatments.