Figure 1.

Study Design and Characteristics of Discovery and Verification Sets

(A) Overall study design. Maternal serum samples were collected at both UCSD site (n = 48) and Sera Prognostics site (n = 164). The samples were split into a discovery set (n = 141) and verification set (n = 71) with matching gestational ages and disease severity. Within each set, there were roughly 2× the number of controls as cases.

(B) Distribution of cases (49 in discovery and 24 in verification) and controls (92 in discovery and 24 in verification).

(C) Distribution of GABD.

(D) Correlation between discovery and verification AUCs. Scatterplot of the discovery and verification AUCs for candidate predictors for pre-eclampsia is shown. Best-fit linear trendline and r² value are shown.

See also Figure S1.