Table 2.
Study Subject Demographics and Clinical Characteristics of 141 Patients in the Discovery Cohort and 71 Patients in the Verification Cohort
| Discovery Case (n = 49) | Discovery Control (n = 92) | p Value Discovery Case versus Control | Verification Case (n = 24) | Verification Control (n = 47) | p Value Verification Case versus Control | p Value Discovery versus Verification | |
|---|---|---|---|---|---|---|---|
| Mean maternal age (year) | 30.1 ± 6.4 | 29.0 ± 6.1 | 0.29 | 26.8 ± 6.7 | 27.7 ± 6.1 | 0.59 | 0.88 |
| Median gravidity | 3 ± 1.7 | 2 ± 1.7 | 0.24 | 2 ± 2.5 | 2 ± 1.0 | 0.72 | 0.85 |
| Median parity | 1 ± 1.1 | 1 ± 1.5 | 0.93 | 1 ± 2.3 | 1 ± 1.2 | 0.75 | 0.96 |
| Mean BMI | 30.7 ± 10.1 | 26.1 ± 7.8 | 0.02 | 33.7 ± 9.6 | 27.6 ± 7.5 | 0.01 | 0.95 |
| No. subjects with diabetes | 10 (20.4%) | 9 (9.8%) | 0.12 | 5 (20.8%) | 5 (10.6%) | 0.29 | 1.0 |
| Race/ethnicity | 0.40 | 0.57 | 0.11 | ||||
| White – non-Hispanic | 24 (49.0%) | 50 (54.3%) | 7 (29.2%) | 20 (42.6%) | |||
| Hispanic | 12 (24.5%) | 25 (27.2%) | 13 (54.2%) | 17 (36.2%) | |||
| African-American | 7 (14.3%) | 9 (9.8%) | 3 (12.5%) | 8 (17.0%) | |||
| Asian | 4 (8.2%) | 3 (3.3%) | 0 (0.0%) | 1(2.1%) | |||
| Pacific Islander | 1 (2.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| Other | 1 (2.0%) | 5 (5.4%) | 1 (4.2%) | 1 (2.1%) | |||
| Median GABD (week) | 24.3 ± 3.0 | 24.0 ± 3.1 | 0.31 | 24.1 ± 2.9 | 23.5 ± 3.3 | 0.39 | 0.71 |
| Median GA delivery (week) | 36.3 ± 6.4 | 39.2 ± 1.2 | <0.01 | 36.2 ± 3.2 | 39.3 ± 2.5 | <0.01 | 0.67 |
| No. preterm deliveries | 27 (55.1%) | 3 (3.3%) | <0.01 | 15 (60%) | 3 (6.5%) | <0.01 | 0.49 |
| Mean birthweight (g) | 2,589.5 ± 922.7 | 3,464.8 ± 465.4 | <0.01 | 2,733.6 ± 893.5 | 3,213.0 ± 675.9 | 0.03 | 0.87 |
| No. IUGR | 11 (7.9%) | nonea | NA | 5 (7.0%) | nonea | NA | 1.0 |
a
As IUGR was an inclusion criterion for the case group, there were no subjects with IUGR in the control group.