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. 2020 May 19;1(2):100013. doi: 10.1016/j.xcrm.2020.100013

Table 3.

Univariate Predictors and Reversals Selected in Discovery and Confirmed in Blinded Verification

Univariate/Bivariate Numerator Denominator GABD Window Discovery Mean AUC—Full Discovery Mean AUC—Early Discovery Mean AUC—Middle Discovery Mean AUC—Late Verification Mean AUC—Full Verification Mean AUC—Early Verification Mean AUC—Middle Verification Mean AUC—Late Chromosome Numerator Chromosome Denominator Numerator Denominator Tissue Atlas Max/(Max − 10%) Numerator Tissue Atlas Max/(Max − 10%) Denominator Carrier Subclasses Numerator Carrier Subclasses Denominator
B hsa-miR-127-3p hsa-miR-485-5p F 0.66a 0.57 0.61a 0.70a 0.67b 0.70b 0.68b 0.68b chr14 chr14 Y Y placenta/liver platelets CD63
B hsa-miR-4732-3p hsa-miR-941 E 0.55 0.81a 0.57 0.58 0.53 0.80a 0.63a 0.68a chr17 chr20 Y Y RBC liver input_AGO2 input_CD63
B hsa-miR-1273h-3p hsa-miR-3173-5p E 0.57 0.83a 0.57 0.53 0.62a 0.82a 0.57 0.56 chr16 chr14 platelets platelets
B hsa-miR-155-5p hsa-miR-3173-5p E 0.56 0.76a 0.55 0.50 0.58 0.76a 0.59 0.51 chr21 chr14 lymphocytes platelets
B hsa-miR-150-3p hsa-miR-193b-5p M 0.63a 0.76a 0.73a 0.58 0.70a 0.58 0.71a 0.76a chr19 chr16 Y lymphocytes liver
B hsa-miR-1285-3p hsa-mir-378c M 0.56 0.61a 0.70a 0.54 0.65b 0.63b 0.70b 0.67b chr02|chr07 chr10 RBC liver input_AGO2 input
B hsa-miR-4732-3p hsa-miR-381-3p E 0.53 0.82a 0.63a 0.57 0.50 0.80a 0.46 0.56 chr17 chr14 Y Y RBC placenta input_AGO2
B hsa-miR-320b hsa-miR-155-5p L 0.58 0.62a 0.60a 0.70a 0.54 0.70a 0.59 0.68a chr01 chr21 liver/RBC lymphocytes PLAP
B hsa-miR-181a-5p hsa-miR-155-5p L 0.59 0.58 0.59 0.70a 0.52 0.70a 0.54 0.69a chr01|chr09 chr21 placenta lymphocytes
B hsa-miR-26b-5p hsa-miR-155-5p L 0.59 0.53 0.61a 0.69a 0.55 0.65a 0.51 0.72a chr02 chr21 liver/placenta lymphocytes PLAP
B hsa-let-7g-5p hsa-miR-155-5p L 0.59 0.58 0.60 0.70a 0.53 0.69a 0.56 0.68a chr03 chr21 RBC lymphocytes CD63
B hsa-miR-4443 hsa-miR-155-5p L 0.57 0.64a 0.56 0.72a 0.53 0.73a 0.56 0.68a chr03 chr21 liver lymphocytes PLAP
B hsa-miR-425-5p hsa-miR-155-5p L 0.58 0.60 0.58 0.70a 0.54 0.69a 0.54 0.69a chr03 chr21 Y platelets/placenta/liver/RBC lymphocytes CD63
B hsa-miR-146a-5p hsa-miR-155-5p L 0.57 0.63a 0.54 0.70a 0.57 0.61a 0.47 0.68a chr05 chr21 platelets lymphocytes input_CD63
B hsa-miR-25-3p hsa-miR-155-5p L 0.59 0.57 0.57 0.71a 0.52 0.75a 0.56 0.69a chr07 chr21 Y RBC lymphocytes input
B hsa-miR-151a-3p hsa-miR-155-5p L 0.58 0.63a 0.57 0.71a 0.54 0.70a 0.55 0.68a chr08 chr21 platelets lymphocytes CD63
B hsa-miR-320a hsa-miR-155-5p L 0.58 0.62a 0.61a 0.71a 0.54 0.69a 0.61a 0.67a chr08 chr21 placenta/liver lymphocytes PLAP
B hsa-miR-30d-5p hsa-miR-155-5p L 0.58 0.64a 0.56 0.71a 0.54 0.71a 0.57 0.68a chr08 chr21 Y placenta lymphocytes PLAP
B hsa-miR-126-3p hsa-miR-155-5p L 0.58 0.62a 0.57 0.70a 0.55 0.67a 0.54 0.73a chr09 chr21 platelets lymphocytes CD63
B hsa-miR-146b-5p hsa-miR-155-5p L 0.57 0.64a 0.55 0.70a 0.56 0.63a 0.58 0.69a chr10 chr21 liver lymphocytes CD63
B hsa-let-7i-5p hsa-miR-155-5p L 0.60a 0.60a 0.61a 0.74a 0.55 0.69a 0.55 0.71a chr12 chr21 RBC lymphocytes CD63
B hsa-miR-26a-5p hsa-miR-155-5p L 0.56 0.65a 0.56 0.70a 0.54 0.69a 0.55 0.69a chr12|chr03 chr21 platelets/liver/ placenta lymphocytes CD63
B hsa-miR-625-3p hsa-miR-155-5p L 0.58 0.64a 0.59 0.73a 0.54 0.67a 0.48 0.69a chr14 chr21 platelets lymphocytes CD63
B hsa-miR-423-5p hsa-miR-155-5p L 0.59 0.60 0.59 0.70a 0.55 0.73a 0.46 0.72a chr17 chr21 Y platelets lymphocytes AGO2
B hsa-miR-451a hsa-miR-155-5p L 0.61a 0.57 0.60a 0.72a 0.54 0.69a 0.46 0.70a chr17 chr21 Y RBC lymphocytes AGO2
B hsa-miR-125a-5p hsa-miR-155-5p L 0.58 0.63a 0.61a 0.71a 0.51 0.75a 0.57 0.70a chr19 chr21 Y placenta lymphocytes PLAP
B hsa-miR-99a-5p hsa-miR-155-5p L 0.58 0.60a 0.56 0.70a 0.56 0.68a 0.46 0.71a chr21 chr21 Y liver lymphocytes
B hsa-let-7b-5p hsa-miR-155-5p L 0.60 0.60 0.61a 0.71a 0.54 0.75a 0.46 0.73a chr22 chr21 Y RBC lymphocytes
B hsa-miR-516b-5p hsa-miR-155-5p L 0.55 0.72a 0.47 0.70a 0.54 0.72a 0.64a 0.69a chr19 chr21 Y placenta lymphocytes PLAP
B hsa-miR-363-3p hsa-miR-155-5p L 0.59 0.58 0.61a 0.70a 0.53 0.73a 0.54 0.69a chrX chr21 Y RBC lymphocytes
U hsa-miR-516b-5p E 0.49 0.81a 0.64a 0.59 0.54 0.75a 0.70a 0.52 chr19 Y placenta PLAP
U hsa-miR-941 M 0.65 0.69a 0.70a 0.64a 0.56 0.49 0.73a 0.62 chr20 Y liver input_CD63

Information pertaining to the GABD window, performance (area under the curve [AUC]) in the discovery and verification cohorts, tissue sources (calculated), and associated carrier subclasses (calculated) is listed. Mean AUCs for discovery and verification sets for each GABD window. Chromosome: chromosome on which each miRNA is encoded. miRNA Cluster: if a given miRNA is located in a miRNA cluster, a “Y” is entered. Tissue Atlas: for each miRNA. The cell or tissue type with the highest percentage, and with percentages within 10 percentage points of the highest percentages, are listed in decreasing abundance in the “max/(max − 10%)” columns. Associated Carrier Subclasses: for miRNAs that show differential enrichment in one or more carrier subclasses by immunoprecipitation, the enriched subclass(es) are listed. See also Tables S3 and S4 and Figure S2. E, early; F, full; L, late; M, middle.

a

Mean AUC values between 0.6 and 0.8.

b

miRNAs for which the verification mean AUCs for each GABD window and averaged across all GABD windows columns are >0.6.