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. 2020 Aug 6;5(15):e137869. doi: 10.1172/jci.insight.137869

Figure 1. Induction of DDR1 expression in lung adenocarcinoma (LUAD) cell lines following cisplatin treatment.

Figure 1

Murine (ChA14.6 and ChA14.9) and human (A549 and H460) KRAS-mutant lung adenocarcinoma (LUAD) cell lines were treated with cisplatin (4 and 20 μM) and assessed for DDR1 expression either by qPCR (A) or by Western blot (B) after 24 or 48 hours as indicated. Extracts from untreated control cells (Untr) were used as controls. α-Tubulin was used as loading control. Cells were treated with 1 μM doxorubicin during 24 hours as a positive genotoxic control. (C) Quantification of 3 independent Western blot experiments normalized to untreated controls as shown in B. Data were analyzed using 1-way ANOVA followed by Dunnett’s multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.001. Data are shown as the mean ± SEM of 3 independent experiments.