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Representative action potential traces from (A) WT (WT1) control iPSC-CMs (n = 10) and (B) RYR2 Dup 1-c2 mutant iPSC-CMs under baseline conditions (n = 10) and (C) RYR2 Dup 1-c2 mutant (n = 8) and (D) RYR2 Dup 2-c2 mutant (n = 5) iPSC-CMs following ISO (100 nM) treatment. DAD events are indicated by the arrow.
