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. 2020 Aug 20;5(16):e138722. doi: 10.1172/jci.insight.138722

Figure 5. Effect of triple combination on the CFBE41o- lipidome.

Figure 5

(A) PCA score plot for the control and triple combination (VX-661/VX-445/VX-770) comparison. The 2 groups are separated in unsupervised data analysis. (B) Volcano plot for the same comparison. The features with a fold change greater than 1.5 (FDR-adjusted P = 0.1) are indicated in purple along with the regulation status following treatment with Trikafta.