Figure 1. KCa3.1 participates in sodium absorption and anion secretion of mouse and human epithelium.

Representative short-circuit current traces of (A) WT and (B) Kcnn4^–/– mouse tracheae used to calculate the following: (C) V_te, (D) R_te, (E) I_SC, (F) Amiloride-sensitive current, (G) amiloride-insensitive current, (H) cAMP-induced anion current and Ca⁺²-activated anion current at (I) peak or (J) plateau phases; n = 9 for each group. (K) Representative Ussing chamber recordings of HBECs incubated with TRAM-34 and controls showing amiloride addition. (L) Summary of TRAM-34 effect on amiloride-sensitive Na⁺ absorption; n = 6 different cell cultures for each condition. Statistical differences were calculated using rank-sum test. Detailed values including data for Kcne3^–/– are included in Table 1.