Figure 3. The genetic silencing of Kcnn4 reduces sodium absorption and increases MCC in the Scnn1b^tg/+ mouse trachea.

(A) Representative I_sc traces showing the extent of amiloride-sensitive currents in the Scnn1b^tg/+ (n = 6) and double mutant (n = 4) mice tracheae. (B) Summary of amiloride-sensitive currents as shown in (A), P value calculated using ANOVA on ranks. Polar plots (75 μm radius) of the trajectory of beads placed in (C) Scnn1b^tg/+ (222 beads) and double mutants (126 beads), from 5 different experiments each. Detailed electrical parameters are given in Table 1. Calculated (D) speed of particles and (E) total distance from the experiments shown in C. Differences were calculated using ANOVA on ranks. MCC, mucociliary clearance.