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. 2020 Aug 17;7(6):e876. doi: 10.1212/NXI.0000000000000876

Figure 4. GA decreases the fraction of senescent EBV-specific CD8+ T lymphocytes.

Figure 4

Patients' and healthy donors' cells were labeled with CD3, CD8, pentamers, KLRG1, and CD127 and analyzed by flow cytometry. (A) Representative plots showing the KLRG1/CD127 expression pattern in pentamer + CD8 T cells from 1 HD, 1 untreated NEDA patient with MS, and 1 GA-treated patient with RRMS. Senescent cells are defined as CD127- KLRG1+. (B and C) Cumulative data relative to senescent cells. Mean values and SDs (error bars) are conveyed. p Values were calculated with the ANOVA and Tukey multiple comparison test. ***p < 0.001; ****p < 0.000. ANOVA = analysis of variance; EBV = Epstein-Barr virus; GA = glatiramer acetate; HD = healthy donor; KLRG1 = killer cell lectin-like receptor G1; NEDA = no evidence of disease activity; nt = not treated; RRMS = relapsing-remitting MS.