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. 2020 Aug 21;7(6):e880. doi: 10.1212/NXI.0000000000000880

Figure 3. The influence of CSF NfL on treatment strategies and disability outcomes.

Figure 3

Box plots representing (A) the influence of CSF NfL on No Treatment/No Escalation vs Treatment/Escalation strategies. The horizontal black line indicates the age-specific reference value for CSF NfL (<30: 290 pg/mL, 30–39: 380 pg/mL, 40–59: 830 pg/mL). (B) EDSS change at 1-year follow-up as a function of treatment strategies (i.e., No Treatment/No Escalation vs Treatment/Escalation) (n = 203). Box-whisker plots represent median, quartiles, and 1.5 × interquartile range. p Values were obtained using the Kruskal-Wallis test. EDSS = Expanded Disability Status Scale; NfL = neurofilament light chain.