Figure 5. Analysis of cortical thickness stratified for disease duration.

(A, C, E, and G) Baseline. (B, D, F, and H) Additional effects over time. Patients with amyotrophic lateral sclerosis (ALS) with a short disease duration show cortical thinning limited to the rostral anterior cingulate cortex at baseline (A) and additional cortical changes over time in motor and frontotemporal regions (B). Patients with a longer disease duration show cortical involvement of similar frontotemporal regions at baseline and no progressive cortical changes during follow-up.