Figure. Regional white matter volume differences between a cohort of patients without dementia with probable cerebral amyloid angiopathy (CAA) and 2 other age-matched cohorts: a cohort of patients with Alzheimer disease (AD) and a healthy control cohort.

Voxel-based morphometry through statistical parametric mapping 12 software was used to explore the regions where white matter volume (adjusted for age, sex, and total intracranial volume) was significantly lower in patients without dementia with probable CAA when compared to age-matched healthy controls and patients with AD (lighter colors correspond to regions of worse white matter atrophy in CAA). A general linear model was performed, and regional surface maps were generated using a threshold of p < 0.001 (with additional correction for multiple comparisons).