(A–D) Relationship between serum neurofilament light (NfL), glial
fibrillary acidic protein (GFAP), tau, and ubiquitin C-terminal
hydrolase-L1 (UCH-L1) measured at enrollment and diffusion tensor
imaging (DTI) fractional anisotropy (FA) for corpus callosum (CC)
integrity measured at enrollment. The ß estimates and
p values are from regression models, covaried for
age, education, and sex. We also assessed the relationship with
univariate the Spearman rank correlation (ρ).