Figure 4. Association between serum NfL at enrollment and cross-sectional measures of GM, WM, and CC volumes.

(A–F) Association between serum neurofilament light (NfL) measured at enrollment and gray matter (GM), white matter (WM), and corpus callosum (CC) volumes assessed at enrollment (all patients with traumatic brain injury). The ß estimates and p values are from regression models, covaried for age, education, sex, and total intracranial volume. We also assessed the relationship with univariate Spearman rank correlation (ρ). Brain regions were normalized to total intracranial volume before analysis with ρ.