Skip to main content
. 2020 Jun 9;94(23):e2404–e2411. doi: 10.1212/WNL.0000000000009582

Figure 4. Synaptic plasticity was influenced by ApoE isoforms.

Figure 4

Human brain tissues (middle temporal gyrus) were collected from ApoE-ɛ4 noncarriers (n = 25, dot) and carriers (n = 21, square). (A) Representative Western blot bands for postsynaptic density protein 95 (PSD95) and synapsin 1 (Syn1) were shown. (B) PSD95 and (C) Syn1 levels were plotted to compare carriers vs noncarriers. β-actin was used as an internal control. **p < 0.01, carriers vs noncarriers. The Pearson correlation curve was depicted. Syn1 was correlated with the (D) DRS Z score, (E) Boston Naming total (60 items) Z score, and (F) AVLT total learning Z score. AVLT = Auditory Verbal Learning Test; DRS = Dementia Rating Scale.