Table 5.
Laparoscopy-assisted hybrid minimally invasive Ivor Lewis esophagectomy versus totally minimally invasive Ivor Lewis esophagectomy
| No of studies | No of patients | RR/SMD (95% CI) | I 2 (%) | |
|---|---|---|---|---|
| Pneumonia (RR) | 4 | 297 | 1.83 (0.71–4.71) | 32 |
| Pulmonary complications (RR) | 4 | 298 | 1.45 (0.98–2.15) | 4 |
| Anastomotic leakage (RR) | 7 | 723 | 0.55 (0.38–0.80) | 0 |
| Chyle leakage (RR) | 4 | 177 | 1.05 (0.21–5.28) | 0 |
| RLN palsy (RR) | 2 | 197 | 4.18 (0.52–33.57) | 0 |
| Wound infection (RR) | 2 | 187 | 7.33 (1.39–38.61) | 0 |
| Severe complications (RR) | 2 | 197 | 0.85 (0.57–1.27) | 0 |
| All complications (RR) | 2 | 197 | 1.02 (0.79–1.32) | 0 |
| Reoperation (RR) | 3 | 238 | 2.21 (0.44–11.06 | 0 |
| Postoperative mortality (RR) | 5 | 323 | 0.85 (0.17–4.19) | 0 |
| Irradical resection (RR) | 4 | 298 | 1.63 (0.39–6.73) | 0 |
| Intensive care LOS (SMD) | 2 | 110 | 0.45 (−0.77–1.67) | 89 |
| Hospital LOS (SMD) | 4 | 273 | −0.05 (−0.31–0.21) | 9 |
| Extracted lymph nodes (SMD) | 4 | 273 | 0.17 (−0.09–0.42) | 6 |
| Operating time (SMD) | 4 | 273 | −0.47 (−0.72–-0.23) | 0 |
| Blood loss (SMD) | 2 | 197 | 0.66 (0.36–0.95 | 0 |
RR, relative risk; SMD, standardized mean difference; CI, confidence interval. For dichotomous parameters, RR > 1 favors TMIE and RR < 1 favors HMIE. For continuous parameters, SMD >0 favors TMIE and SMD <0 favors HMIE, except for the parameter ‘Extracted lymph nodes’, in which SMD >0 favors HMIE and SMD <0 favors TMIE