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. 2020 Jul 3;6(27):eaba2735. doi: 10.1126/sciadv.aba2735

Fig. 3. PAP response, TRAIL release, and infiltration of I-P-OMVs in melanoma spheroids.

Fig. 3

(A) Photothermal response of I-P-OMVs (0 to 5 μg/ml) to NIR irritation (2 W/cm2 for 3 min) (n = 3). (B) Changes in the DPBF absorbance spectra in the presence of I-P-OMVs under NIR irradiation (0, 0.6, and 2 W/cm2). (C) DPBF absorbance in the presence of I-P-OMVs at 412 nm under NIR irradiation (0, 0.6, and 2 W/cm2) (n = 3). (D) TRAIL release profiles at 37°C without or with NIR irradiation (2 W/cm2) (n = 3). (E) CLSM images of 3D tumor spheroids incubated with Dil-OMVs, Dil-R-OMVs, and Dil-P-OMVs. (F and G) CM-Dil fluorescence intensity in different depths of 3D tumor spheroids incubated with Dil-OMVs (F), Dil-R-OMVs (F), and Dil-P-OMVs (G). All data are represented as means ± SD. ***P < 0.001 and **P < 0.01.