. 2020 May 12;51(3):1079–1092. doi: 10.1007/s42770-020-00284-3

Table 4.

The FIC of combination (antibiotic/POM/ROS) against planktonic cells of P. aeruginosa PS-1

Antibiotics	MIC (mg/ml)			FIC ¹ of combinations (antibiotic/POM/ROS)	FIC index² (∑FIC)	Type of interaction³
Antibiotics	Antibiotic	POM/ROS	Combinations (antibiotic/POM/ROS)	FIC ¹ of combinations (antibiotic/POM/ROS)	FIC index² (∑FIC)	Type of interaction³
PRL	1.024	3.13/6.25	0.032/1.56/3.125	0.030/0.5	0.531	Additive
CDZ	0.512	3.13/6.25	0.002/1.56/3.125	0.004/0.5	0.504	Synergism
IPM	1.024	3.13/6.25	0.004/1.56/3.125	0.004/0.5	0.504	Synergism
CN	1.024	3.13/6.25	0.002/1.56/3.125	0.002/0.5	0.502	Synergism
LEV	0.512	3.13/6.25	0.002/1.56/3.125	0.004/0.5	0.504	Synergism

FIC, fractional inhibitory concentration; 1, FIC = MIC _combination/MIC _alone; 2, FIC index (∑FIC) = FIC of plant mixture + FIC of antibiotic 3, synergism (FIC index < 0.5); additive (FIC index ranging from 0. 5 to1.0); indifferent (FIC index ranging from 1.0 to 2.0) and antagonism (FIC index > 2). POM: Pomegranate; ROS: Rosemary; PRL: Piperacillin; CDZ: Ceftazidime; IPM: Imipenem; CN: Gentamycin; LEV: Levofloxacin