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. 2020 Aug 28;10:100. doi: 10.1186/s13550-020-00678-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Combined image set shows two representative subjects with metastatic head and neck cancer (HNC). Shown from left to right are the axial CT (upper is soft-tissue window, lower is lung window), [¹⁸F]FDG PET, and [¹⁸F]FSPG PET images. The first subject (row a) has a right level 2 cervical lymph node, while the second subject (row b) has multiple pulmonary nodules of which a right apical nodule is shown. The black arrows indicate the lesions. Any unmarked uptake on the PET scans is physiologic. Of note, both the cervical node and the pulmonary nodule are subcentimeter in size (9 mm for the cervical node (a) and 7 mm for the right upper lobe pulmonary nodule (b)). The lesions are seen on all modalities, and both the [¹⁸F]FDG and [¹⁸F]FSPG PET images have uptake in both the cervical node (SUV of 8.7 and 2.6, respectively) and the pulmonary nodule (SUV of 2 and 1.5, respectively)