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. 2020 Aug 28;10:100. doi: 10.1186/s13550-020-00678-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Combined image set shows three representative subjects with metastatic colorectal cancer (CRC). Displayed from left to right are the axial CT (upper two rows are soft-tissue window, lowest row is lung window), [¹⁸F]FDG PET, and [¹⁸F]FSPG PET images. The first subject (row a) has a rectal mass and an adjacent small perirectal lymph node, the second subject (row b) has a liver metastasis, and the third subject (row c) has pulmonary metastases on the left and an ipsilateral mediastinal lymph node metastasis. The black arrows indicate the lesions. Any unmarked uptake on the PET scans is physiologic. The lesions are seen on all modalities, and both the [¹⁸F]FDG and [¹⁸F]FSPG PET images have similar uptake across all lesions (SUV rectal mass (a) 15.8 and 12, liver lesion (b) 17.4 and 16.1, and pulmonary metastasis (c) 7.4 and 8.3, for [¹⁸F]FDG and [¹⁸F]FSPG, respectively)