Fig. 4. Ketamine inhibits Cav1.2-mediated calcium channel activity.

a–c are representative Ba²⁺ current traces of two microelectrode voltage-clamped Xenopus oocytes, previously injected with water (a, n = 5 oocytes) or with cRNA encoding Cav1.2 subunits, recorded in the absence (b, n = 10 oocytes), or presence of ketamine (c n = 10 oocytes). d, e summarize data from a–c showing dose-dependent inhibition of Cav1.2-mediated Ba²⁺ current by ketamine (d n = 10 oocytes) or nifedipine (e n = 5 oocytes). f, g are representative whole cell current traces of fresh isolated BSM cells in the absence (f n = 8 BSM cells) or presence (g n = 8 BSM cells) of 100 µg ml⁻¹ ketamine. h Summarizes data showing ketamine inhibition on Cav1.2-mediated Ba²⁺ current in freshly isolated mouse BSM cells as shown in f, g. Data are presented as mean values ± SD. Source data are provided as a Source Data file.