Fig. 9. SMCav1.2+/− mice exhibit altered urodynamics mimicking ketamine cystitis.

a–c Representative VSA images from SMCav1.2^+/− mice showing increased number of voids and smaller void size, both corrected by Bay k8644 (2 mg/kg i.p.). e–g (n = 31 filters for wild type, and n = 18 filters for SMCav1.2^+/− with or without Bay k8644), summarized data indicating SMCav1.2^+/− mice have increased numbers of primary voiding spots (PVS: voiding spot area ≥80 mm²) and reduced PVS size (f). d CMG traces from SMCav1.2^+/− mice. h–i (n = 5 mice) summarized voiding interval (h), basal pressure (i), threshold pressure (j), peak pressure (k), and compliance (l), which were quantitated by paired t-test. SMCav1.2^+/− mice showed reduced voiding interval, smaller voiding size, reduced peak pressure and compliance, each rescued by infusion of Bay k8644 (200 nM). Data are shown as box and whiskers, center line is the median of the data set, box represents 75% of the data, and bars indicates whiskers from minimum to maximum. Data are analysed by two tailed Student’s t-test (e–g) and two tailed paired t-test (h–l). P < 0.05 is considered to be significant and P values are given above the bars. Source data are provided as a Source Data file.