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. 2020 Aug 28;11:4323. doi: 10.1038/s41467-020-17953-4

Fig. 5. Pharmacological activation of Wnt signaling in MB reduces tumor formation and improves overall survival.

Fig. 5

a Representative histology images of xenografts generated from patient-derived treatment-refractory MBs following L807mts treatment (n = 6 per MB line) contain a reduction in overall tumor burden when compared with xenografts treated with PBS control (n = 6 per MB line). b SU_MB002 (n = 12, p = 0.0001) c RCMB40 (n = 12, p = 0.000011), treated with L807mts (n = 6, individual mice per MB line) contain a significant reduction in overall tumor volume when compared with PBS control-treated xenografts (n = 6, individual mice per MB line). Xenografts of d SU_MB002 (n = 12; median survival L807mts 49.5 days, PBS 32.0 days; p = 0.0008, n = 12), and e RCMB40 (n = 12; median survival L807mts 52.9 days, PBS 38.0 days; p = 0.0005) treated with L807mts display a significant survival advantage when compared with control PBS-treated mice. Histology image scale bar = 5000 μm. Panels (b, c) contain error bars expressed as mean ± standard error (mean) using two-tailed, unpaired Student’s t test. Panels (d, e) analyzed using log-rank (Mantel–Cox) test. ****p < 0.0001.